Systems consolidation across distributed circuits has to rely on the global coupling of internal network dynamics, to enable the coordinated reactivation of previous experiences across remote brain regions.
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These bistable dynamics are pair-wise coordinated 11, 12, 13, 14, 15, giving rise to emergent spatiotemporal neural population dynamics that reactivate awake memory patterns 16, 17, 18, 19, 20, while their interaction has been postulated to support memory consolidation 11, 13, 21, 22, 23 and the transfer of memories to their permanent cortical storage 24, 25.ĭuring offline brain states (such as sleep), the cortex is sensory disconnected from the environment. In contrast, during slow-wave sleep, the cortex is in a bistable state, characterized by alternations between generalized silent DOWN, and synchronous UP states across thalamocortical circuits 5, 7, while the hippocampal circuits transiently synchronize during sharp-wave bursts associated with high-frequency ripple oscillations 10. During active behavioral states, sensory-motor integration loops engage widespread circuits and give rise to theta oscillations that entrain local dynamics and provide the substrate for the coordination of the information flow and population coding 5, 6, 8, 9. Global, slow neuronal oscillations have been proposed as a mechanism that enables the coordinated interaction between remote brain regions, serving as a source of synchronization in the local circuits and promoting synaptic plasticity 6, 7. Despite a growing understanding of local plasticity rules and neural activity correlates systems-level mechanisms that enable processing and transfer of information across distributed circuits are not well understood. Over the past century, cortical and subcortical structures of the limbic circuit and the medial temporal lobe have been identified as critical elements of the memory circuit, involved in the formation and retrieval of episodic memories during online states 1, 2 and their consolidation during sleep 3, 4, 5. These results highlight breathing, a perennial brain rhythm, as an oscillatory scaffold for the functional coordination of the limbic circuit that supports the segregation and integration of information flow across neuronal networks during offline states. During offline states, the respiratory modulation underlies the coupling of hippocampal sharp-wave ripples and cortical DOWN/UP state transitions, which mediates systems memory consolidation. Using large-scale recordings from a number of cortical and subcortical brain regions in behaving mice, we uncover the presence of an intracerebral respiratory corollary discharge, that modulates neural activity across these circuits. Here we address the hypothesis that breathing acts as an oscillatory pacemaker, persistently coupling distributed brain circuit dynamics. However, little is known about the mechanisms that synchronize and coordinate these processes across widespread brain regions during offline states. man/man3/LastKnownRequestProcessed.3.Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits.lib/X11/locale/zh_HK.big5hkscs/XLC_LOCALE.lib/X11/locale/zh_HK.big5hkscs/XI18N_OBJS.lib/X11/locale/microsoft-cp1256/XLC_LOCALE.lib/X11/locale/microsoft-cp1255/XLC_LOCALE.lib/X11/locale/microsoft-cp1255/Compose.lib/X11/locale/microsoft-cp1251/XLC_LOCALE.lib/X11/locale/microsoft-cp1251/Compose.lib/X11/locale/georgian-academy/XLC_LOCALE.
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